Loss of Brain Nerve Cells in Alzheimers Disease

Loss of Brain Nerve Cells in Alzheimers Disease Fig-6: Showing neuronal death due to inflammation and oxidative stress. Adenosine Deaminase (ADA), and Neuropsychiatric Disorders:- Adenosine is a neuromodulator of brain function that is uniquely positioned to integrate excitatory and inhibitory neurotransmission and neuroprotective actions in pathological conditions. The understanding of adenosine production and release in the brain is therefore of fundamental importance and has been extensively studied (ADA-8). Adenosine metabolism in the brain is very important, and its dysregulation has been implicated in pathophysiology of several neuropsychiatric disorders, since it modulates the release of several neurotransmitters such as glutamate, dopamine, serotonin and acetylcholine, decreases neuronal activity by pos-synaptic hyperpolarization and inhibits dopaminergic activity. Adenosine deaminase participates in purine metabolism by converting adenosine into inosine (ADA-7). (The production and metabolism of adenosine is given in the Fig.7) Adenosine deaminase (ADA, adenosine aminohydrolase, EC 3.5.4.4), an enzyme involved in the metabolism of purine nucleosides, catalyses the irreversible hydrolytic deamination of adenosine (Ado) and 2 ´-deoxyadenosine (2 ´-dAdo) to inosine and 2 ´- deoxyinosine, respectively. The enzyme is widely distributed in vertebrate tissues and plays a critical role in a number of physiological systems. In nature, several isoforms of ADA are known that differ by molecular mass, kinetic properties and tissue distribution (ADA-2). It plays a role in the development and functioning of T lymphomonocytes. Levels of this enzyme increase during the mitogenic and antigenic response of lymphocytes, whereas ADA inhibitors limited the blastogenesis of lymphocytes; thus, ADA levels are higher in T cells than in B lymphocytes. ADA was previously recognized as a cytosolic enzyme; however, it is currently known to be present at the surfaces of cells, in particular T lymphocytes, to interact with some membrane proteins, including CD-26/DPP IV, and is considered an ecto-enzyme. This co-localization of DPP IV/CD-26 and ADA at T cells is important for the activation of T cells because the interaction of ADA and CD-26 at the T cells results in co-stimulatory signs responsible for the activation of the T cell receptor (ada ). Long considered to be an immune-privileged site because of the presence of the blood-brain-barrier (BBB) and the lack of a lymphatic system, it is now well-established that the brain is fully capable of mounting inflammatory responses in response to invading pathogens, trauma, or ischemic events (G-17). Fig. 7 Pathways of adenosine production, metabolism and transport, with indications of the sites of action of various enzyme inhibitors. Abbreviations are as follows: ADA, adenosine deaminase; AK, adenosine kinase; AOPCP, a,b-methylene ADP; DCF, deoxycoformycin; EHNA, erythro-9-(2-hydroxy-3-nonyl)adenosine; es, equilibrativesensitive nucleoside transporters; ei, equilibrative- insensitive nucleoside transporters; 5-IT, 5-iodotubercidin; NBMPR, nitrobenzylthioinosine; PDE, cAMP phosphodiesterase; SAH, S-adenosyl homocysteine. Activation of oligodendrocytes results in secretion of inflammatory molecules, such as nitric oxide (NO), cytokines, and prostaglandins and most  notably in upregulation of several chondroitin sulfate proteoglycans, including NG2, which contributes to the growth-inhibitory environment that prevents regeneration of axons in the injured CNS. In summary, in acute situations and when short lived, neuro-inflammatory mechanisms generally limit injury and promote healing; however, when neuro-inflammation becomes chronic it can damage viable host tissue, resulting in compromised neuronal survival and cognitive impairment. For these reasons, inflammation in the CNS has been appropriately described as a two-edged sword (G-17). Again Hcy activates cytokines and pro-inflammatory molecules, such as IL-1beta, IL-6, IL-12, IL-18, IL- 1 receptor antagonist, C-reactive protein, adhesion molecules (P-selectin, E-selectin, ICAM-1), and metalloproteinases (MMP-9). In addition, Hcy up-regulates reactive oxygen species, leading to activation of NF-kappa B, the pro-inflammatory nuclear regulatory molecule (G-3). On the other hand, neuropsychiatric disorders have been shown to be accompanied with some immune-inflammatory alterations. In this regard in order to make a contribution to the understanding of the ongoing immune disturbance in neuropsychiatric disorders, serum ADA activity was determined in neuropsychiatric patients and compared with healthy controls. Intracellular and extracellular levels of adenosine are tightly controlled by specific nucleoside transporters and several important enzymes, which include adenosine deaminase (ADA) and 5’-nucleotidase (5’-NT) (ADA-4). ADA activity is known to be increased in inflammatory diseases characterized by T-cell activation and proliferation. Therefore, ADA is considered a marker of T-cell activation. In addition, overproduction of reactive oxygen species (ROS) including hydrogen peroxide (H2O2), superoxide anion (Oà ¢- _ 2); nitric oxide (NOà ¢- ) and singlet oxygen (1O2) creates a condition known as oxidative stress, resulting in the amplification of the inflammatory response (ADA-6). Studies related to ADA levels in neuropsychiatric patients are virtually non-existent. ADA and schizophrenia Adenosine may play a role in the pathophysiology of schizophrenia, since it modulates the release of several neurotransmitters such as glutamate, dopamine, serotonin etc. Dutra GD et al (2009) showed that decreased ADA activity in schizophrenic patients than in control subjects (ADA-7). Brunstein MG et al (2007) reported that the schizophrenic patients treated either with typical antipsychotics or clozapine showed increased serum ADA activity compared to controls (ada-b sub 14). ADA and Depression Elgun et al (1999b) reported that decrease ADA activity in patients with depression compared with controls, might reflect the impaired immune system in depression (A sub). Mackiewicz et al (2006) showed that ADA levels did not change with age in rats (A sub). Herken H et al (2007) showed that ADA levels of the patients were significantly higher than the controls (abstract ref). An increasing body of evidence implicates both brain inflammation and oxidative stress in the pathogenesis of Alzheimers disease (A-9). Inflammation is a cause, contributor, or secondary phenomenon in the disorder inflammatory pathways are altered in the periphery in AD, together with evidence that increased peripheral inflammation leads to more neurodegeneration and accelerated disease progression in animal models. Antioxidants defense:- Humans have evolved a highly complicated antioxidant defense system to combat the damaging effects of free radicals. Under physiological conditions, overproduction of ROS and RNS and their neutralization is prevented by the activity of endogenous anti-oxidative defense system (AOS). Antioxidants are a broad group of compounds which constitute the first line of defense against free radical damage thus are essential for maintaining optimum health and well-being. They are protective agents, capable of stabilizing or deactivating free radicals before they attack cells. Being beneficial compounds, they control free radical formation naturally and help organisms to deal with oxidative stress caused by free radicals (antiox 4) (Fig. 8). Antioxidant system encloses enzymes like superoxide dismutase; catalase, glutathione peroxidase, and other antioxidant-regenerating enzymes such as gluthatione reductase; dehydroascorbate reductase and glucose-6 phosphate dehydrogenase, that maintains reduced NADPH; hydrophilic scavengers like urate, ascorbate, gluthatione, flavonoids; lipophilic scavengers, like tocopherols, carotenoids and ubiquinone. The great majority of antioxidants are supplied with the diet and includes polyphenols, lipoic and ascorbic acid, carotenoids, lycopene, quercetine, genstein, ellagic acid, ubiquinone and indole-3 carbinole. In fact, in the biological systems, the normal processes of oxidation produces highly reactive free radicals and each of this administered compounds is involved in the physiological redox balance preventing damage to the tissues (antioxi 3). Enzymatic Antioxidants An important part of the intracellular antioxidant defense systems are antioxidant enzymes such as superoxide dismutase, catalase and peroxidases. Superoxide dismutase (SOD) SOD is found abundantly in many organisms, from microorganisms to plant and animals, since superoxide radicals (O2−†¢) are toxic to living cells, oxidizing and degrading biologically important molecules, such as lipids and proteins. The role of SOD is to protect aerobic cells against O2−†¢ action. It catalyzes O2−†¢ dismutation reaction into H2O2 and O2−†¢. There are three known types of SOD: two copper-zinc containing SOD (CuZn-SOD), one in cytosol and one bound to the vascular endothelium ( also called â€Å"extracellular SOD† (ECSOD)) and a manganese containing SOD (MnSOD), which is localized in the mitochondrial matrix (antio-4). This enzyme specifically catalyzes the dismutation of O2−†¢ anion into H2O2 and O2−†¢ in a pH-independent medium (5–9.5). Manganese SOD is the mitochondrial form of this dismutase. Its active site contains manganese and reduces the O2−†¢ generated during the ETC. T he amount of MnSOD inside the cell varies according to the number of mitochondria found in each cell type. This enzyme has antitumor activity. Extracellular SOD also contains copper and zinc in its structure and is the main extracellular SOD. It is synthesized inside the cells and secreted into the extracellular matrix (G-66, G-71, SOD-1). Fig. 8- Mechanism of action of antioxidants Catalase (CAT) Catalase is an enzyme that reacts very effectively with H2O2 to form water and molecular oxygen and with H donors (methanol, ethanol, formic acid, or phenols) with peroxidase activity. Catalase protects cells against H2O2 generated inside them. Although CAT is not essential to some cell types under normal conditions, it has an important role in the acquisition of tolerance to ONS in cellular adaptive response (G-10). Glutathione peroxidase (GPx) and Glutathione Reductase GPx is an enzyme that contains a single selenocysteine (Sec) residue in each of four identical subunits, which are essential to the enzyme’s activity. Humans have four different GPx types: (1) a classic cytosolic form; (2) a membrane-associated GPx phospholipids, (3) another cytoplasmic enzyme, gastrointestinal GPx; and (4) an extracellular type. All GPx enzymes are known to add two electrons to reduce peroxides by selenols forming (Se-OH). GPx antioxidant properties allow them to eliminate peroxides as potential substrates for Fenton’s reaction. Glutathione peroxidase works together with glutathione tripeptide (GSH), which is present in cells in high (micromolar) concentrations. The substrate for the GPx catalytic reaction is H2O2 or organic peroxide ROOH. Glutathione peroxidase catalyzes hydroperoxide reduction using GSH, thus protecting mammalian cells against oxidative damage. Glutathione metabolism is one of the most important antioxidant defense mechanisms (G-10). Together with classic H2O2-removing enzymes (CAT and GSH-Px), the enzyme thioredoxin reductase (TrxR) is a seleno-flavoprotein which forms the thioredoxin system together with the protein thioredoxin (Trx) and NADPH. This is an effective system to reduce proteins in disulfide form and it also participates actively in the removal of H2O2 and other peroxides (G-57). 4) Thioredoxin reductase (TrxR) TrxR catalyzes the reduction of Trx especially, but in humans it can also reduce other substrates, such as vitamin C. This reductase also catalyzes the reduction of disulfide proteins and it is involved in countless vital processes, such as DNA synthesis and the regulation of apoptosis. Additionally, this system also donates electrons during DNA synthesis, and NADPH and human TrxR by themselves or with Trx are efficient electron donors to this human plasma peroxidase, which allows this enzyme to reduce hydroperoxides even when there are low levels of GSH available (G-52). There are three identified TrxR isoenzymes: cytosolic (TrxR-1), mitochondrial (TrxR-2), and a third isoenzyme which has been isolated from the mitochondrion of rat testes (TrxR-3). TrxR-1 has wide substrate specificity, since it is responsible for reducing not only Trx but also hydroperozides, lipoic acid, ubiquinone, and dehydroascorbate. Thus, the Trx system is regarded as having a crucial role maintaining a cell’s redox state. It may also have a role in the system which regulates the expression of redox-sensitive genes through the activation of transcription factors (G-58). Non-enzymatic Antioxidants Vitamin E (ÃŽ ±-tocopherol) The lipid-soluble antioxidant vitamin E is localized in the cell membrane and has been targeted for its relation to atherosclerosis and vascular function. Decreased concentration vitamin E (ÃŽ ±-tocopherol) scavenges the chain-carrying peroxyl radicals rapidly and interrupts the chain propagation. During this reaction, vitamin E becomes a free radical called tocopheryl, which is less reactive than the lipid radical and migrates to the surface of the membrane to be transformed again into tocopherol through the action of ascorbic acid (G-72) (Fig-9). However, in elevated concentrations the tocopheryl radical may act as pro-oxidant. On the other hand, ÃŽ ²-carotene is a hydrophilic precursor of vitamin A and large concentrations accumulate in the membranes of certain tissues. Its antioxidant activity is related to the removal of O2−†¢ and free radicals formed during lipid peroxidation. This activity is due to its conjugated double-bonded structure that can dislocate unpaired electrons, which enables ÃŽ ²-carotene to physically quench singlet oxygen without degradation (G-65). Vitamin C (ascorbic acid) Vitamin C is a hydrosoluble antioxidant, which facilitates its diffusion into intra- and extracellular matrices. Its antioxidant potential is related to direct removal of O2−†¢ and HO†¢. Furthermore, it contributes to regenerating oxidized vitamin E; however, vitamin C also has pro-oxidant activity. It may be the one compound, in addition to HO†¢, that can convert Fe3+ into Fe2+, which then reacts with H2O2 to form OH. Vitamin C is a water-soluble vitamin that participates in a large number of cell functions (antio 5). All

Cultural Awareness and Competence Essay

Cultural awareness and competence refers to the ability of an individual to postpone judgment and prejudice toward other people based on their religious background, race or ethnicity, sexual orientation or gender, age, and such, and also one’s capability of understanding, accepting, and even adapting to unfamiliar culture, points of view, beliefs, ideologies, traditions, etc. Raising one’s cultural awareness and competence requires allocating time and exerting effort in learning and understanding the concepts of multiculturalism or cultural diversity. For instance, developing specific learning goals and a plan of action is an excellent start to promoting cultural awareness. My desire to raise my cultural awareness of two specific groups, particularly homosexuals and individuals belonging to the black population, require that I set personal learning goals and a plan of action that will guide how I am going to go about the process of learning and understanding culture based on race, ethnicity, and sexual orientation. For this particular case, I believe that two of my learning goals should include reviewing the history of the African-American people, particularly the reasons why they are being discriminated upon, as well as the unfamiliar cultural practices and traditions and the meaning and significance that deepens or intensify their culture, and understanding the personal sentiments and emotions of homosexuals in order for me to recognize where they are coming from and be able to empathize with them in the process regarding their unfortunate situation especially when it comes to being judged or discriminated because of their sexual orientation. In order for me to realize the aforementioned learning goals, I plan to conduct research by reading books, magazines, newspaper articles, journal publications, research studies, online articles, and such, about black people and homosexuality. Moreover, I feel that there is a need for me to socialize with individuals belonging to the African-American culture and homosexuals in order for me to obtain first-hand information about their sentiments, experiences, knowledge, and such. I believe that through my willingness and determination to immerse myself into the African-American culture and the world of homosexuality, I will be able to promote cultural awareness simply by being conscious of the issues that they burden themselves with. EXODUS International is an online website that discriminates against homosexuals. It is a religion-based organization that provides assistance for individuals who want to â€Å"leave homosexuality. † The organization subtly reiterates that homosexuality is against the will and the word of God and that â€Å"leaving homosexuality† is a way for individuals to live a better life according to what God wants for His children. Moreover, within the lines of EXODUS International’s mission and objectives, the organization clearly mentions that homosexuals will not be able to live a fulfilling and holy life. (EXODUS International, 2005) The blog â€Å"Stuff White People Like† is an online website that discriminates against African-Americans simply because the site is devoted to discuss issues that generalize on the likes and dislikes of white people. The website lists more than one hundred things that white people like. I believe generalizing and labeling things or situations as something that is true or amenable only for a certain race is close to prejudice and bias since one is limiting these things and situations to a particular race only despite the fact that other individuals from diverse racial backgrounds may share the likes and dislikes of white people. (Stuff White People Like, 2009) I can honestly say that I am non-judgmental or prejudice in any way against any group of people in society depending on their race, ethnicity, religion, age, sexual orientation, gender, and such. I am also proud to say that my parents raised me well. Although my family is American and adheres to Christianity as a religion, we do not judge other people from different racial backgrounds and religions. Because of my parents and family, I was able to understand that people are different from each other, and although we are different, I do not have the right to judge other people because of it. Moreover, I understand that people have different frames of mind or worldviews and we see things and situations differently. Handling the matter only requires respect and acceptance and the understanding of cultural diversity or multiculturalism. Judging from my self-assessment of my cultural awareness and competency, I believe I will be able to uphold moral and ethical principles in my profession, especially with issues that concern multiculturalism. Perhaps the only challenge that I would have to face is how I am going to develop and increase my cultural awareness to cope with multicultural trends and new information. References EXODUS International. (2005). Thinking of Leaving Homosexuality? Retrieved January 7, 2009, from Exodus International. Website: http://exodus. to/help/? option=com_content&task=view&id=327&Itemid=147 Harvey, C. & Alard, M. J. (2008). Understanding and Managing Diversity, 4th Ed. Prentice Hall. Stuff White People Like. (2009). Retrieved January 7, 2009, from Stuff White People Like. Website: http://stuffwhitepeoplelike. com/

Hallowed Ground – Creative Writing

One damp morning in the spring of 1951, an elderly woman sat in her drawing room, and stared out of the Edwardian window, stretching from the floor to the ceiling. The velvet green curtains fluttered slightly against a draft. This is her place of rest, were she chose to lead the rest of her life peacefully. She gazed into her garden. Her drawing room was vacant when compared with the beauty of nature. The walls were lined with great masterpieces, her tables decorated with beautiful and rare Ming vases. She sat upright against the silk tapestry cushions of the chair. She loved the outdoors, and always felt uncomfortable with the four walls enclosing her, no matter how beautifully they were decorated. She always adored her garden, the white and pink roses in her numerous and perfectly arranged, symmetrical beds. The garden had limestone stairs, and she peered out of the window, down the grey-white steps, to a garden that stretched to the horizon. The grass was a pure deep green. And in the centre, a pond, stretching horizontally from one end of the garden to the other, the only means of crossing was an old bridge of pale wood with small engravings of dragons lining its railings. She watched the golden red carp glitter in the soft morning sun under the water's surface. Her garden shone with pink and white blossoms. The flowers, at this time of year were mainly spring pansies, daffodils and bluebells, dripping with morning dew. The rose bushes stretched all the way across the left side of the brick wall, ruining its foundations. She remembered old age, spreading through her body like the flower, ruining her strength. Her once able body was frail. Time was running out: the hourglass had tipped. She leant forward to the man across the table, sipping his tea and waiting patiently for a reply. She felt his harsh gaze in her eyes. â€Å"So, Miss Amanda Daley†, he began, â€Å"are you considering ever using our services again, perhaps writing another book or novel? I hope you know, and of course you do, being a lady of worth, that our services are at the best of prices and of the highest quality.† His words remained unanswered, and she carried on staring out of the window. His pinstripe suit and unmarked suede shoes were intimidating, and clearly he was a wealthy man, ignorant to suffering. She was uncomfortable in his company, and like a small child, looked at the floor. And yet, she hated silence, the social void, representing her lack of communal knowledge, and gossip could spread about her past. She sat with her back erect, causing her pain. And yet, she felt that etiquette overcame physical pain, as her father had always taught her. Her back throbbed. She was indifferent to her publication anyhow, since she grew increasingly ill, relief succumbed to etiquette. Her back relaxed. And, as she suspected, she felt a kind of paternal betrayal. Finally, she brought herself to mutter a few words, â€Å"Yes, thank you, I know. I shall send a telegram when necessary. My book will be finished in about three weeks. Come to collect the papers when I call.† She led him to the front door, where he stepped into his automobile. ‘Being a lady of worth'- these words irritated her, span around in her head, but she kept calm and showed no discontent. His car vanished through the drive, and she saw no point in waving him off. She had work to do. She was to begin her story. She sat in the drawing room, asked the maid to fetch her a blanket and hot tea, and sat at the oak table near another window. She stared at her aged hands and wrinkled face in the reflection of her silver teapot, each line representing a time in her life, and she also noticed her hollow eyes. The blue veins emerged on her fingers, as if her condition had just appeared overnight. But alas, this was not so. They did not just emerge, but the veins remained; no medicine could possibly cure it. She had simply not cared before. There were more important things to handle previously; age was a meagre aspect amongst her losses. She sat back, and allowed the painful memories to enter her mind. (2) Her mother, whom she adored with all her heart, would tell her stories when she sat up in bed, and listened with the same intent, even though the stories were often alike. Once her mother had left, and she had said her prayer, she looked out of her window to the star-studded sky, against the black sheet of infinity, and rested against it, was the chalky moon. She shut her eyes. At sunrise, she saw her father leaving the house, as usual. He shut the door with the same pessimism. His job was tedious, though he was too arrogant with false masculinity to ever admit it. He was well educated, well dressed, well paid and an owner of a leading company. He paid for servants to look after her family, even though her mother saw it as an intrusion of privacy. The house was situated on the edge of the sea cliffs, and the path following down to the ocean was lined with jagged rocks, sharp enough to cut. An hour later she tore her shoe on the steep path when walking down to the bay. As she stared deep into the horizon, she wondered what was beyond it. The sea lapped at her bare feet and she felt a slight spiritual familiarity with her surroundings, an eternal bonding of the vast and treacherous sea with her small, trusting heart. The sea sang into her ears, the wind caressed her skin and the sea appeared to be studded with thousands of diamonds against a turquoise backdrop. The sun blazed and her skin shone pink. She returned to a silent house. â€Å"Mother†, she called, looking uncertain, bracing herself. A splutter came from upstairs, and the servants were nowhere to be seen. She saw her mother coming down the stairs. The reply was not as dire as she had expected or it was and she simply did not understand. â€Å"Annabella†, her mother said. She spoke in a quiet tone, one that would have been soothing if it were not for the overwhelming fear that she could sense in her mother's eyes and expression. â€Å"Your father has been injured at his factory. Now, I don't expect you to understand this but we are treading on thin ice. We may be in slight financial trouble, but there is no reason to worry.† But there was. Annabella could sense it. What was a pretty Victorian house was now wrought with depression. Annabella stopped walking down the beach, and fell asleep in tears. The month later, she was roused by Victoria, her maid, and was told to dress. She met her mother at the breakfast table. Her beautiful green eyes were now veiled with tears, her curled blonde hair was now matted and greasy. She managed to force out the words, but Annabella knew exactly what she was about to hear. The house was silent again, no coughing, no cries and no shouts. She whimpered and tensed herself. All she heard was, â€Å"He's gone.† No sounds from her father, no reminders of the infected wound. She did not cry. She was grieving ever since he was hurt, and she knew it. Her father had died after a wild fever and her family suffered in horrible grief, his death believed to have been caused by the infected wound. Once she understood the cruel consequences of her father's death; a growing anger came over her, like a flame on oil. â€Å"Why has he left us?† she asked herself. â€Å"He had not taken any care; no money was ever left except for the pittance that remained after debts and taxes. There was no longer any financial help. He left my mother in hysterical tears, a sorry and disconcerting spectacle to their children.† (3) Even though it was many years since her father's funeral, she remembered the light oak coffin in which her father's body rested comfortably against a white silk tapestry. She remembered the echoing aisle sounds of shoes against the limestone floor, her silent mother and wailing brother, still young and too small to understand. During the final stages of his life, he had grown incredibly weak and thin. Two dark pits surrounded his eyes and the red and brown liquid seeping from his mouth. Her mother was always kneeling at his bedside with a damp cloth in order to calm the fever. The injury in his chest had become infected, and his whole chest was swollen, and his temperature soared. He often vomited. He cried during the night and woke up the house. Her mother never allowed servants to look after him, and she stayed by him, feeling that it was her responsibility. The memories of her father stayed with Annabella for the rest of her life, traumatising her, and yet provided her with an inner strength and understanding of the temporality of life. Unable to hold her pen any longer Annabella sat back, shut her eyes and waited till she had the enthusiasm to start the next chapter. The book, rather than being a release of the emotional torments, became a burden of pain.

The Animal Of Animal Welfare Act - 1851 Words

Animal Welfare Act Casandra Sasaki Eagle High School Abstract The Animal Welfare Act, passed in 1966, establishes guidelines for the protection of animals used for research and other purposes, defines the requirements for facilities housing those animals, and outlines the procedures for inspection and maintenance of those facilities by government entities. This paper explores the pros and cons of the act as well as the effectiveness of the guidelines and their enforcement. Finally, it makes several recommendations based on the evidence presented. Policy Identification and Explanation The policy that I am researching is: â€Å"United States Code: CHAPTER 54—TRANSPORTATION, SALE, AND HANDLING OF CERTAIN ANIMALS.† (Animal Welfare Act, 2015). This is the Animal Welfare Act. Because the Animal Welfare act has so many parts to it, the section I am focusing on is: â€Å" §2143: â€Å"Standards and certification process for humane handling, care, treatment, and transportation of animals† (Animal Welfare Act, 2015). This specific section is focusing on animal testing in research facilities across the United States. It tells the minimum requirements for animals’ housing, treatment, care, sanitation, etc. This section also states the requirements for procedures done on animals. Section three, part B states: â€Å"the principal investigator considers alternatives to any procedure likely to produce pain or distress† (Animal Welfare Act, 2015). The Animal Welfare Act is a federal law,Show MoreRelatedAnimal Testing and The Animal Welfare Act1417 Words   |  6 PagesMany scientists claim that without animal testing, medical breakthroughs and research would not have progressed to where it is today. 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Johnson saw this and the heard cries and sorrow of the people and didn’t agree with what was going on. On August 24th, 1966 President Johnson created a nameless act in order to ensure and protectRead MoreAnimal Welfare Act Of The Ringling Brothers Circus1506 Words   |  7 PagesAnimals in captivity are being forced to perform for human entertainment, but have to go through different forms of mistreatment to succeed in their performances. When it comes to billion dollar companies, such as, SeaWorld Entertainment and Ringling Brothers and Barnum Bailey circus, abuse their animals at a very young age in return of profit from admission ticket sales. The Animal Welfare Act regulates housing, exhibiting, c are, licensing, and care for animals in captivity. Although, it onlyRead MoreAnimal Experimentation At University College London1685 Words   |  7 PagesI. Introduction a. 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The law also applies to people who are responsible for animals, such as breeders and those who keep working animals. (APGAW. No Date)  ¬ The